Thursday, April 30, 2009

Bedwetting ADHD Kids and Depressed Dads: Is there a connection?

ADHD and Bedwetting (Nocturnal Enuresis): How are the two related?

There is a relatively recent publication that came out within the last couple of weeks on the relatively high rate of occurrence in bed wetting (enuresis) among ADHD children, which I believe is worth sharing. We have previously investigated this ADHD and bed wetting connection (note that bed wetting may be more likely to be seen alongside the inattentive subtype of ADHD). However, this study offers some additional insight into this strange association between the two disorders. Here are some important points worth mentioning:


  • Overlapping Drug Treatment for ADHD and bedwetting: It stands to reason that if a particular drug or agent is effective in treating multiple disorders, there may be a distinct possibility that those two or more disorders may share some type of underlying cause(s) or defect(s). For example, Tofranil or Imipramine, a drug used to treat enuresis and depressive disorders can possibly be useful as a treatment option for ADHD. We have also investigated the potential role of Reboxetine as a potential ADHD treatment in previous entries. Some work has found Reboxetine to be useful in treating therapy-resistant enuresis as well.

  • Prevalence of Enuresis in ADHD: Enuresis refers to urinary incontinence which is limited to the night-time. Additionally, the term is typically limited to individuals over the age of 5 (i.e. a 3-year-old child who frequently pees in their pants would not be considered as suffering from enuresis, at least in the context of this study). The article cites other studies in which the rate of bedwetting (enuresis) in ADHD is as high as 30%, although other studies have it down around 10-20%. Still, compared to the general population, (factoring in things such as the age of the child, of course)the high rate of bed wetting in ADHD is especially noteworthy. There is some evidence from other studies that ADHD and enuresis may be more intricately linked than previously imagined. For example, one particular study has shown that treating urinary incontinence has a higher rates of failure in children with ADHD vs. non-ADHD children.

  • The role of Oppositional Defiant Disorder (ODD) on Bed wetting: The study examine several different psychiatric disorders which frequently occur alongside of (or are comorbid to) ADHD. These include depression, anxiety disorders, obsessive compulsive disorders, tic disorders, nail biting, bruxism (teeth grinding), conduct disorders and oppositional defiant disorders. However, out of all of these different disorders which often appear alongside ADHD, the only one which exhibited a statistically significant correlation to increases in bedwetting was oppositional defiant disorder. Interestingly, oppositional defiant disorders have been associated with bedwetting in other ADHD studies.

    As its name suggests, Oppositional Defiant Disorder is a disorder in which a child exhibits disobedience, irritability and hostility towards authority figures beyond the range of normal age-appropriate behaviors. Of course there is a significant gray area with regards to what is age appropriate, especially when the child's environment is considered. Nevertheless, Oppositional Defiant Disorder (or ODD) is much more than just routine temper tantrums. Oppositional Defiant Disorders may also be associated with auditory processing issues and ADHD. It is somewhat interesting that anxiety disorders, which have also been correlated to oppositional behaviors, did not elicit a significant positive correlation to bed wetting.

  • The autonomic nervous system as a potential underlying cause of ADHD, bedwetting and Oppositional Defiant Disorders: The autonomic nervous system is the part of the nervous system responsible for involuntary muscle actions such as digestive processes, blood vessel contraction, etc. It is subdivided into the sympathetic and parasympathetic nervous systems, which often act in a sort of "push-pull" opposition to each other. For example, the sympathetic nervous system does things such as boosting heart rate and constricting blood vessels, while the parasympathetic nervous system is in charge of activities such as reducing heart rates and relaxing sphincter muscles (which plays a role in bladder control).

    Typically, the sympathetic and parasympathetic components of the nervous system are kept in balance, but this balance may be thrown out of whack and result in numerous disorders. For example, it is believed that the parasympathetic nervous system is over dominant in cases of Oppositional Defiant Disorders (ODD). The study found that for ADHD and Oppositional Defiant Disordered children, functions such as heart rate were controlled excessively (if not almost exclusively) by the parasympathetic portion of the nervous system (while non-ODD and non-ADHD children had both sympathetic and parasympathetic controls operating on their heart rates. This suggests a common underlying imbalance among the different components of the nervous system which is common to ADHD and ODD individuals and often separates them from the non-ADHD'ers. Interestingly, other studies have indicated that bedwetting or generalized incontinence problems may also be caused by an overactive parasympathetic nervous system, which suggests that ADHD, ODD and night-time bedwetting may all share some underlying causes within the nervous system.

  • Connection to Parental Depression: I personally found this observation to be interesting. The study found that the prevalence of bedwetting in ADHD children was higher if the father (but not the mother) of the child was suffering from some sort of major depressive illness. The article did not express an opinion as to whether these depressive symptoms were due in part to the child's bed wetting problems or whether there was some underlying mechanism at work.

  • ADHD medications may Influence Enuresis: The authors highlight some other works in which popular ADHD medications may either increase or decrease the risk of bedwetting in ADHD children. For example, the article highlighted a case study (by the same author) in which treatment with methylphenidate induced nocturnal enuresis. Methylphenidate is one of the most common ADHD drugs, and often goes by the common trade names Ritalin, Concerta, Metadate and Daytrana (the patch form of the drug). Of course this is based on only one individual case, but for those of you who have read this blog on a frequent basis, will know that I like to report on some of these abnormal occurrences (for reference sake, here is an earlier blog post I have done on the possible connection between methylphenidate and excessive talking. While based on an isolated case report, I believe that this zany potential side effect was at least worth a mention). On the flip side, however, the non-stimulant alternative ADHD drug, Atomoxetine (Strattera) can be a useful treatment for enuresis. This blogger would personally like to see additional studies on whether ADHD children with a comorbid bedwetting condition actually saw a better reduction in their ADHD symptoms while on Strattera than while on methylphenidate. If this were the case, then bedwetting may actually served as a useful tip-off as to which type of ADHD medication would work best for that particular child.

Add to Technorati Favorites

52 comments:

Anonymous said...

Learn about a new way to treat ADHD:

www.adhdfree.net

gerkfritz@brainbalancecenters.com said...

First let me say I love your blog. Great information!
Next, you might want to check out persistent primitive (neonatal) reflexes as a cause of many co-morbidities (including enuresis). The work of Jane Ayers and of Sally Goddard-Blythe come to mind. We work with kids who have neuro-developmental disorders and frequently find any number of persistent primitive reflexes.
Thanks again.
Dr. Gary

Patti said...

Interesting article. My 8 y.o. son has ADHD treated with Focalin and up until 3 months ago had frequent (2x week) bed wetting. 3 months ago we started him on 1/2 mg of melatonin to help with sleeping issues and we haven't had an accident since. Doctors have no explanation.

Anonymous said...

I had the same experiace with my son when he was 7. He has ADHD and constantly wet the bed. If we gave him half a melatonin tablet, an hour before he went to sleep he NEVER wet his be. If he did it was because we forgot the tablet. The problem stopped when he hit puberty and has never been an issue since.

Heather said...

My daughter's night wetting occured with less frequency when she began taking adderall. Once she was given prozac in addition, the wetting completely stopped. During the summer, she stopped Adderall but continued with Prozac and nightly bed wetting returned. She woke up dry after the first day Adderall was taken this school year. What a relief for my nine year old (and for my non-stop washing...I couldn't bear to put her back in pull-ups this summer!) !

I love your blog...thanks for all the great info!

Heather

Anonymous said...

my son is 13, when had started taking Adderall his bedwetting reduced dramatically, when he started taking it consistently (not just school days), it has all but disappeared.

Paros said...

My 9 year old son's incidents of enuresis declined until he was put back on stimulant medication. Since then (beginning early Jan.) it has escalated significantly. I think I may try the melatonin.

Heather M said...

My 9 year old daughter was diagnosed with ADHD in April and has been taking Focalin for a little over a month now. She is also a nightly bed wetter. A week ago, she ran out of pull ups and decided she wanted to try and sleep without one. She has not had an accident since. This connection is fascinating to me.

Anonymous said...

I am really thankful that you have taken the time to compile this information. My 10 year old son has had a significant problem with bed wetting every night. He was placed on 10mg of Strettara a while back for ADD (no unusual hyper-activity) and his bed wetting stopped the first night. If we miss a dose, he has an accident. I wet the bed until I was a freshman in college and so did my father. Prior to my father ‘s death he had a life long battle with anxiety (self-medicated with alcohol). Likewise, I suffer from depression and anxiety and take the maximum dose of Effexor to help. My son shows all the earmarks of high personal and social anxiety. We are currently in conversation with our physician as to possible treatments. As your blog suggests there must be a common thread.

Anonymous said...

My 9 yr. old son has always had a bedwitting problem. As a young child, loud noises really bothered him (auditory processing). He used to take desmopressin for the bedwetting, which did work, but after years it stopped working. Recently, his attention problems were getting worse, and he just started Concerta 36mg 3 weeks ago. He has not had an accident since. However, he's had difficulty falling asleep, so we've been giving 500mcg of Melatonin. So...which is it? The Concerta or the Melatonin? My guess is Concerta. Strangely, my other son, who is more hyperactive than inattentive, takes both concerta and melatonin. He has never had an enuresis problem. but he does talk excessively. I believe this is due to comorbidity of mild Asperger's-like symptoms, as he talks even MORE excessively without the concerta.

Anonymous said...

My 9 year old daughter took various stimulants last year and stopped bedwetting when she was on them. We took her off medication for the past 6 months and she began wetting the bed again. We started her on Concerta 18 mg about 1 month ago and she immediately stopped wetting the bed. However, we just upped her dose to 27 mg 5 days ago and she has wet the bed before 11 pm at night every night since then!! She has taken a 1 mg Melatonin tablet ever since she went off stimulants 6 months ago and we continue to give it to her now. So, why would she start wetting again - and so early in the night - at the exact same time as we upped her Concerta? It seemed like the Concerta was helping her stay dry. We are so confused.

Anonymous said...

My son was diagnosed at age 8 although we pretty much knew for 4 years prior that he had it. He was a bed wetter (nocturnal and daytime). He wet the bed most nights and had daytime accidents about 3-4 times a week (usually when playing).

We started him on a very low dose of concerta (18 mg) and the wetting completely stopped. Not just reduced, but stopped. Dr had no idea why when we told him.

He takes Concerta every day. But just this past Tuesday, we forgot to give him his pill before he went off to school. By the time we realized it, it was too late in the day to give him his pill. When he got home, he played outside with a friend and had a small accident. That night he wet the bed very heavily.

I have no doubt there is a direct correlation between his ADHD and the Bed wetting and a direct correlation between taking the Concerta and eliminating the bedwetting (as well as the ADHD symptoms).

Manuel Mota Castillo said...

Do you really believe in ODD. That will go against the theories of several "founders" of psychiatry who stated that before the age of 10 years children have chosen if they are going to be "rules followers" or unruly. In my experience ODD is a symptoms of several treatable illnesses such as OCD, Social Anxiety Disorder, bipolar spectrum disorder, etc.
Please check this website: www.psychiatricanswers.com

Manuel Mota-Castillo, M.D.

Manuel Mota Castillo said...

I believe that ODD is not a real diagnosis but a symptom of several treatable illnesses such as OCD, Social Anxiety Disorder, bipolar spectrum disorder, etc. I have never found one child that continued exhibiting "oppositional-defiant" behavior after proper treatment for the real condition. a child has introyected social moreWe should remember that it is well-accepted in our field that by the age of 10 years s and respect (or disrespect) for rules. A "good boy" does not become "ODD" just because he enjoys been bad.
We should pay more attention to family history and also remember that amphetamines worsen aggressive behavior and anxiety.

Manuel Mota Castillo said...

Just an observation to the mother that mentioned Asperger and ADHD. If you check the DSM-IV, the official APA classification of diagnoses does not allow to Diagnose ADHD in a child with a pervasive development disorder. The reason is very logical: There is already a reason for the lack of attention. Sadly many autistic children are given amphetamines with the bad consequence of a severe worsening of the obssesions and temper tantrums.

muebles en barcelona said...

For my part everyone ought to glance at it.

Anonymous said...

Hi I just wanted to mention that my 8 yr olf son has been on Strattera for a year. He is a huge bedwetter. He wets, two to three times per night. Even when I limit his drinks after dinner. Being on Strattera has not improved this at all for us.

Anonymous said...

Also, as per my bedwetting comment. My son's father does suffer from depression and substance abuse.

sports handicapping services said...

hello friends I think that if there must be connection simply live together that children are like sponges that absorb everything going on around whether good or bad and these are the consequences

Anonymous said...

Thanks so much for your mention of Methylin being linked to bed wetting. My 7-year-old son has the same problem. On the medication, he's a bed wetter. Off the meds he's not. I think I'll try the melatonin & see if that helps.

Dr. Flanders said...

I am a pediatrician and started biphnetin for a 7 year old with classic ADHD. Not only did his ADHD symptoms dramatically improve, but his primary nocturnal enuresis completely disappeared. If he missed a dose, then that night he wer his bed. Have you ever seen this before? Could it be that there is residual psychostimulant in his system causing a lighter sleep?

Anonymous said...

www.adhdfree.com

I have accidents all the time but not when I was on Addroll. I told my parents that it was the ADHD but they don't beleive in ADHD.

I use to hide my problems by using my brothers diapers. ( I guess that is why girls thought I was cute) when my issue, thanks to maxie pads I was able to hide the isssue.
Later in life my parents told me they knew I still had the problem and desided that as long as I did not have a big problem they were going to keep my secret.

Patricia said...

So, I do not really believe it will have effect.

May said...

Thanks so much for your post, pretty helpful information.

Unknown said...

Thanks for the sensible critique. Me & my neighbor were just preparing to do some research about this.combating depression

Unknown said...

Hi my son is 4 years old and over the top (ADHD) but he has not been diagnosed yet and he also is having the same exact problem. Plz tell me what I can do bc my moms answer to the problem is a spanking all the time. I know he doesn't mean to and his uncontrollable behavior. He is truly a smart child and I don't want to medicate and dumb him down. Plz plz help.

Health and wellbeing said...

Some people use buzzers or alarms attached to night wear, which are triggered by moisture, so she can get up and go to the loo. The aim is to ‘re-programme’ the brain to alert her to wake before she has to wee.

Obat Kutil Kelamin Herbal said...

Good health info

Anonymous said...

As an adult who's always struggled with having nocturnal enuresis I was amazed that when I finally got myself diagnosed with ADHD and started taking ADDERALL I haven't had a night time episode.

Anonymous said...

My 8 year old son's bed wetting stopped within 1 week if starting straterra. As he grew that year, and needed his dosage adjusted, the bed wetting returned. As soon as we increased his Straterra dosage, his bed wetting resolved.

Anonymous said...

My 11 yr old son was diagnosed with ADHD 2 years ago and has struggled with bed wetting all his life. He takes Concerta which gives him insomnia. This summer we took him off his Concerta for a month and he only had 1 accident and was sleeping great. The day after starting him back on his Concerta he wet his bed. This along with the return of this insomnia is frustrating for him. The medication works wonderfully otherwise.

J&S Creations said...

14 year old son adhd bedwetting every night. New diagnosis ODO. Kicked out if 3 schools star athlete kicked off of 3 football teams. 2 weeks into new school wanting him out now. Only in 8th grade. Very anxious with low self esteem but no respect for authority. On probation had tether broke into 2 house stole money. Some OCD....sent to bootcamp. I'm lost please please help I'm loosing my little boy

Unknown said...

We were going through something very similar. My daughter turned 9 over the summer and was so embarrassed to be wearing pull-ups (I totally understand the constant washing! ). When school started she began taking Concerta and the bed wetting reduced from 5-7 times a week to 1-2 times a month.

Unknown said...

We were going through something very similar. My daughter turned 9 over the summer and was so embarrassed to be wearing pull-ups (I totally understand the constant washing! ). When school started she began taking Concerta and the bed wetting reduced from 5-7 times a week to 1-2 times a month.

Anonymous said...

With these details bedwettinghelp@yahoomail.com and +2348141593363 i was able to stop my childhood bed wetting and has been a disgraceful situation in my life. At first my lover was coping with it but 3 months back we where planning for divorce due to my condition but it was through bedwettinghelp@yahoomail.com i saw online that helped me. I can for the past one month i have never bed wet again. Mr Elliot the parcel you sent to me work as you promised and am so happy. Contact him today and stop your bed wetting. He's the best man to discuss with when it comes to bed wetting problems . bedwettinghelp@yahoomail.com and +2348141593363

Melissa said...

Am so glad and thankful to Dr Zadson for helping me cast a spell that stopped my son from bed wetting after 20 years. I came across a testimony online of how this good man helped cure bed wetting just in a few days and i contacted him via eduduzadsontemple@yahoo.com and its been 2 weeks after result and my son sleeps peacefully without any bed wetting. If you are in need of a permanent solution to bed wetting contact this great Dr via eduduzadsontemple@yahoo.com

Unknown said...

Bed-wetting Remedy:
I have been struggling with bed wetting and i was deeply ashamed of myself. I desperately searched for remedies yet was unable to find any, Until I discovered Dr Lababa solution center, I personally dislike roots and herbs but i had no option because am the one that needed the help. He gave me some concoction to drink and behold to my greatest surprise i stop bed wetting. I you need an urgent solution to bed wetting contact Dr Lababa on lababasolutiontemple@gmail.com

Anonymous said...

Okay so I've seen a lot of replies that refer to their child having concerta and stopping bedwetting. My child is on concerta 54 and still is having trouble with bedwetting. This doctor has just prescribed desmopressin for the bed wetting. Does anyone have experience with the combination of both concerta and desmopressin? I guess my main concern is that the combination of the two medications could raise his blood pressure high very high and my family has a history of high blood pressure. Should I be concerned about this and does anyone have any suggestions?

Eliza Mark said...

Are you now over 18 years old, in high school or married and at this age you still bed wet. I will seriously advice you contact Dr Okojie Shango solution temple. He was the one that helped my daughter who was 27 years old and was still bed wetting, he prepared a herbal medicine that stop the bed wetting at once. I am from the United state and i advice if you also have similar situation bed wetting or having diabetes issues or fertility problems, he can also help.In other to contact him you need to quickly contact Dr Okojie on his email: shangosolutiontemple@yahoo.com

Anonymous said...

I never Believe i could stop bed-wetting ever again after several disgrace i face when i visit my friends and spend the night. i Always cry and regret coming to this life. On this faithful and memory day as i was doing a research on the internet i saw how countless people where giving positive comment about this wonderful man called DR Power. I decided to give him a try, to my greatest surprise the bed-wetting stop after 72 hours. I must confess DR Power effective spell remove the disgrace. I must confess if you are out wondering who to solve your bed-wetting problems, hurry up and contact her on dr.powerbedwetsolutionhome@gmail.com

Hayden said...

i am 29 I've been a lifelong bed-wetter, i have all the tests The alarm the tablets and everything is getting worse is really embarrassing and affecting my relationship. know man want to be with me if they find out i still bed wet. there was a guy that disgrace me in because i bed wet on his bed ever since then i am doing my possible best to get out of this problem, i opened up to a friend because i really want to make sure i am out of this situation because it was really embarrassing she introduced me to a called DR uwa who helped her cure her herpes years back. i explained how i wake-up and i find i am wet, DR uwa told me not to cry or worry anymore that he is going to put an end to it. he told me what to do and i followed his instructions and later told me the reason i bed wet and how to put an end to the situation. he prepared a herbal native medicine that i drink for only 2 weeks and all the bad warm that make me to bed wet were flushed out, this is now the 6 months now DR uwa helped me ever since then i have not come across any bed wet, i am very free when sleeping with my boyfriend thank you once again DR uwa in case you need his urgent help contact his direct email: druwaherbalcenter@gmail or call or whatsapp him on +348063930531
Linda Karen
From USA
DOCTOR UWA CAN AS WELL CURE THE FOLLOWING DISEASE:-
1. HIV/AIDS
2. HERPES
3. CANCER ALL KINDS
4. ALS
5. Hepatitis A,B,C
6. Diabetes
7. CHRONIC DISEASE
8. Coronary Artery Disease (Ischemic Heart Disease)
9. Alopecia
10.Bipolar disorder
11.Bedwetting
12.Carpal tunnel syndrome
13.Celiac disease
14.Ear Infections
15.Endometriosis
16.Epilepsy
17.Chlamydia
18.Syphilis
19.Gonorrhea

Anonymous said...

I have been struggling with bed wetting and i was deeply ashamed of myself. I desperately searched for remedies yet was unable to find any, Until I discovered Dr Lababa solution center, I personally dislike roots and herbs but i had no option because am the one that needed the help. He gave me some concoction to drink and behold to my greatest surprise i stop bed wetting. I you need an urgent solution to bed wetting contact Dr Lababa on lababasolutiontemple@gmail.com

Anonymous said...

Do you suffer BED-WETTING? Dr. iyabiye is a herbal doctor and he has the final cure to your problem. He treated my friend with his herbal medication and he will cure yours too. Reach him through email: iyabiyehealinghome@gmail.com Tel: +2348180785770 and save your self from embarrassments.

chellie05855 said...

I am a 48 year old who has been taking provigil for many years to treat narcolepsy. I am on my 2nd cycle of initiating adding Ritalin to help daytime sleepiness. My first cycle ended when after a few days of starting ritilan to the mix, I started wetting the bed. I went off the ritilan and after a few days I stopped. That was over a year ago. My doctor wanted to try adding it again as he thought that maybe it was a fluke. I started Ritalin last Friday and last night (Monday), I was awoken in full stream of urinating. So I truly believe that this may be an adult side effect of Ritalin.

Akami Ayurveda said...

I came across through your blog. I found the valuable information about ADHD treatment from your blog.
Ayurveda Detoxification Therapy

Joseph said...

The great content sharing through your blog. Thanks for sharing.
ayurvedic treatment for brain stroke

Solution To Bed Wetting. said...


I give all thanks to Dr Steve for helping me from the problem of Bed wetting.
Am 28 years old and i have been Bed wetting since I was a child and it has been a bone in the neck, I have taken different Medication with no solution. I could not get married or sleep in my friend House because I will urinate on her Bed.
I got the permanent cure to Bed Wetting from Dr Steven, I took his medication for good one month, and i was cured,Dr Steve has really made me happy in life again. and I promise to tell the whole world about him. contact him on dralegbe@gmail.com or Whats-app him on +1(518)-675-6082

Kayla Boaten said...

What a miracle i never believe there is cure because my doctor tested me Herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this sickness, i can remember some months ago when i was crying all through the night and day that i can’t get cured from this sickness, i found this herbal man email on internet when i was doing research on cure for Herpes i contacted him to found out if i can get help from this sickness, i was so surprise when he told me that he have the herbs cure to it and he sent me the herbal in less down 2-3 days i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 2 weeks, when i went for test after taking the herbal i found out that i am cured i was so happy and surprise, i want to use this opportunity to inform you that there is cured to Herpes you can also contact him for his help as soon as possible so that you can get rid of this sickness once and for all you can reach him through this email: chiefdrlucky@gmail.com or whatsApp him on +2348132777335 You can also contact him on any sickness in this he all have the herbal cure to it


Anonymous said...

i was scam several time not until i meant this doctor called Dr. Yakubu who cured me completely, some times we just need to give a try of herbal Medicine to see for our self. I am very happy today that i do not listen to what people say if not i would have been a dead person by now. I was infected with HERPES SIMPLEX VIRUS in 2015, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so a lady walked to me telling me why I am so sad and i open up all to her telling her my problem, she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i mail him. He told me all the things I need to do and send me the herbal medicine through courier service and also give me instructions to take, which I followed properly. Before I knew what is happening after 3 to 4 days the HERPES SIMPLEX VIRUS that was in my body got vanished and blister dried off . I went to the hospital for a test and it was negative. this man is real and he is the solution to herpes virus. so if you are also heart broken and also need a help, you can also email him dryakubuherbalhealingclinic@gmail.com

Melissa Juanfran said...

At 40 i was still bed wetting until Dr Masade used his AFRICA ROOTS AND HERBS to help my situation and i can gladly say i am totally free, anyone out there can contact Dr Masade on masadeinstanthelp@gmail. com or whatsapp +2349034745112

Unknown said...

I am 36 years old female married but my husband divorced me because I bed-wets, (urinary incontinence) I have been going through it since I was a kid until I got married. I bed-wet both night and day and it was so embarrassing to the extent I don’t sleep at my friend’s house neither do I allow them to sleep at my house, it was also a problem passing a night with my new boy friend and so he was always upset and the relationship was in jeopardy. I was left with no choice than to break the silent and told a friend about what I have been hiding and what ruined my marriage and even threatening my new relationship, she told me how Dr. Uduehi cure her 11 years old son bed-wetting problem and gave me his contact. I reached him and he administered his medication on me and I got free after treatment, it’s been a year since I became free from that embarrassment. You too can be free if interested. Contacts: Tel: +234-708-487-8384 Email: uduehiherbalcare@gmail.com

Health and Sports said...


buy xanax online

BUY ADDERALL ONLINE

buy Klonopin online

buy-tramadol-online

**CLICK HERE TO BUY ONLINE MEDICINES IN USA**

**ORDER HERE FOR OVERNIGHT DELIVERY**

**GET INSTANT OFFER**

**GET EASILY DISCOUNT ON ALL MEDICINES**

**PLACE YOUR ORDER HERE**
$ - Buy Tramadol Online For Anxiety Disorder Get up to 55% Off - $